gocvs GOA and proteome slim Candida GO slim PIR GO slim gene_ontology Generic GO slim 2008-01-04T19:30:00 Prokaryotic GO subset Yeast GO slim cvs version: $Revision: 1.522 $ Plant GO slim calcium channel activity molecular_function Reactome:13088 ISBN:0815340729 GOC:mtg_transport Catalysis of facilitated diffusion of an calcium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. ADP reduction This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider molecular_function term 'ADP reductase activity ; GO:0051061'. GOC:ai OBSOLETE (was not defined before being made obsolete). biological_process triacylglycerol metabolic process biological_process triglyceride metabolism triglyceride metabolic process triacylglycerol metabolism Oxford Dictionary of Biochemistry and Molecular Biology ISBN:0198506732 The chemical reactions and pathways involving triacylglycerol, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triacylglycerols are important components of plant oils, animal fats and animal plasma lipoproteins. MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN progesterone 11-alpha-hydroxylase activity EC:1.14.99.14 progesterone 11alpha-monooxygenase activity progesterone 11-alpha-monooxygenase activity progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating) molecular_function progesterone 11a-monooxygenase activity Catalysis of the reaction: progesterone + donor-H2 + O2 = 11-alpha-hydroxyprogesterone + acceptor + H2O. progesterone 11alpha-hydroxylase activity binding ligand molecular_function GOC:mah GOC:ceb The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. regulation of secondary metabolic process regulation of secondary metabolism Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. GOC:jl biological_process The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues other than as a moiety of nucleic acid. cell wall glycoprotein biosynthetic process cell wall glycoprotein formation cell wall glycoprotein biosynthesis cell wall glycoprotein synthesis cell wall glycoprotein anabolism biological_process PGJ receptor activity prostaglandin J receptor activity molecular_function Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. PMID:12878180 PGJ(2) receptor activity metallocarboxypeptidase D activity MetaCyc:3.4.17.22-RXN EC:3.4.17.22 Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid. molecular_function gp180 (duck) carboxypeptidase D (cattle, human, mouse, rat) EC:1.14.15.4 oxygenase, steroid 11beta -mono- steroid 11-beta/18-hydroxylase activity steroid 11-beta-monooxygenase activity Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. steroid 11-beta-hydroxylase activity steroid 11beta-hydroxylase activity cytochrome P450 CYP11B1 steroid 11beta-monooxygenase activity molecular_function cytochrome P450 CYP11B2 steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) steroid 11beta/18-hydroxylase activity MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN cytochrome p450 XIB1 activity biological_process purine nucleoside triphosphate catabolic process purine nucleoside triphosphate breakdown GOC:go_curators The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. purine nucleoside triphosphate catabolism purine nucleoside triphosphate degradation monoacylglycerol biosynthetic process monoacylglycerol biosynthesis monoacylglycerol synthesis monoacylglycerol anabolism biological_process The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. monoglyceride biosynthetic process monoacylglycerol formation monoglyceride biosynthesis EC:1.14.16.1 phenylalanine 4-hydroxylase activity phenylalanine 4-monooxygenase activity phenylalanine hydroxylase activity L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) PAH activity Reactome:12249 MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. phenylalaninase activity molecular_function EC:1.3.1.30 delta4-steroid 5alpha-reductase (progesterone) 5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity molecular_function progesterone 5-alpha-reductase activity steroid 5-alpha-reductase activity progesterone 5alpha-reductase activity MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH. progesterone 5a-reductase activity respiratory chain cytochrome b6 This term was made obsolete because the activity described by the definition does not exist. To update annotations, use molecular_function term 'electron carrier activity ; GO:0009055'. monoheme class I cytochrome c cytochrome c7 (triheme) cytochrome c3 (tetraheme) diheme class I cytochrome c electron transfer carrier molecular_function Rieske iron-sulfur protein class IIa cytochrome c cytochrome d cytochrome c554 class II cytochrome c flavodoxin cytochrome b class I cytochrome c class III cytochrome c nonaheme cytochrome c flavin-containing electron transporter OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells. high-molecular-weight cytochrome c (hexadecaheme) cytochrome b5 electron transporter activity class IIb cytochrome c class IV cytochrome c alkyne catabolic process alkyne degradation alkyne catabolism alkyne breakdown The chemical reactions and pathways resulting in the breakdown of an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms. http://en.wikipedia.org/ biological_process chitin- and beta-glucan-containing cell wall organization and biogenesis beta-glucan-containing cell wall organization and biogenesis cell wall organisation and biogenesis (sensu Fungi) biological_process GOC:mtg_sensu_feb07 A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the cell wall; as in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). chitin- and beta-glucan-containing cell wall organisation and biogenesis chitin-containing cell wall organization and biogenesis cell wall organization and biogenesis (sensu Fungi) EC:4.3.1.12 ornithine cyclase activity L-ornithine ammonia-lyase (cyclizing; L-proline-forming) ornithine cyclase (deaminating) activity ornithine cyclodeaminase activity MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN molecular_function L-ornithine ammonia-lyase (cyclizing) Catalysis of the reaction: L-ornithine = L-proline + NH3. OCD activity molecular_function PMID:12000961 Interacting selectively with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. phosphatidylserine binding EC:1.14.99.7 squalene-2,3-epoxide cyclase activity Catalysis of the formation of a 2,3-epoxide in squalene. MetaCyc:SQUALENE-MONOOXYGENASE-RXN squalene hydroxylase activity Reactome:12251 squalene oxydocyclase activity squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing) squalene monooxygenase activity squalene 2,3-oxidocyclase activity molecular_function squalene-2,3-epoxidase activity squalene epoxidase activity purine nucleoside triphosphate biosynthetic process biological_process purine nucleoside triphosphate formation purine nucleoside triphosphate synthesis purine nucleoside triphosphate anabolism purine nucleoside triphosphate biosynthesis The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. adenylate deaminase reaction This term was made obsolete because it represents a molecular function. To update annotations, use molecular_function term 'AMP deaminase activity ; GO:0003876'. OBSOLETE (was not defined before being made obsolete). biological_process biological_process Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. regulation of mammary gland epithelial cell proliferation molecular_function palmitoyl-(protein) hydrolase activity palmitoyl-protein thiolesterase activity MetaCyc:3.1.2.22-RXN palmitoyl-protein thioesterase activity palmitoyl-[protein] hydrolase EC:3.1.2.22 Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. palmitoyl-protein hydrolase activity B lymphocyte apoptosis programmed cell death of B cells by apoptosis programmed cell death, B lymphocytes B-lymphocyte apoptosis B cell apoptosis B-lymphocyte programmed cell death by apoptosis programmed cell death of B lymphocytes by apoptosis programmed cell death of B-cells by apoptosis apoptosis of B lymphocytes biological_process B lymphocyte programmed cell death by apoptosis programmed cell death, B-cells programmed cell death of B-lymphocytes by apoptosis apoptosis of B-cells apoptosis of B cells apoptosis of B-lymphocytes The process of apoptosis in B cells. Fundamental Immunology ISBN:0781735149 GOC:add B-cell apoptosis programmed cell death, B-lymphocytes B cell programmed cell death by apoptosis programmed cell death, B cells B-cell programmed cell death by apoptosis GOC:mtg_sensu A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall; as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). cell wall organization and biogenesis (sensu Bacteria) cell wall organisation and biogenesis (sensu Bacteria) biological_process peptidoglycan-based cell wall organization and biogenesis The chemical reactions and pathways resulting in the formation of an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms. alkyne synthesis alkyne formation alkyne biosynthesis alkyne anabolism biological_process alkyne biosynthetic process steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating) EC:1.14.99.10 molecular_function MetaCyc:STEROID-21-MONOOXYGENASE-RXN steroid 21-monooxygenase activity cytochrome P450 CYP21A1 21-hydroxylase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O. cytochrome p450 XXIA1 activity steroid 21-hydroxylase activity The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. pyrimidine nucleoside triphosphate formation pyrimidine nucleoside triphosphate biosynthetic process pyrimidine nucleoside triphosphate synthesis biological_process pyrimidine nucleoside triphosphate biosynthesis pyrimidine nucleoside triphosphate anabolism cAMP breakdown biological_process cAMP degradation 3',5'-cAMP catabolism 3',5'-cAMP catabolic process adenosine 3',5'-cyclophosphate catabolism adenosine 3',5'-cyclophosphate catabolic process cyclic AMP catabolism The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 3',5' cAMP catabolism cAMP catabolic process cyclic AMP catabolic process cAMP catabolism 3',5' cAMP catabolic process mammary gland epithelial cell proliferation The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. GOC:dph biological_process EC:2.4.1.50 collagen hydroxylysyl galactosyltransferase activity UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN procollagen galactosyltransferase activity UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine. hydroxylysine galactosyltransferase activity uridine diphosphogalactose-collagen galactosyltransferase activity molecular_function collagen galactosyltransferase activity UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity UDP galactose-collagen galactosyltransferase activity protein complex localization establishment and maintenance of protein complex localization The processes by which a protein complex is transported to, or maintained in, a specific location. biological_process prenol pyrophosphatase activity EC:3.1.7.1 prenyl-diphosphate diphosphohydrolase activity prenyl-diphosphatase activity prenylphosphatase activity MetaCyc:PRENYL-PYROPHOSPHATASE-RXN Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate. prenyl-pyrophosphatase activity molecular_function EC:1.14.11.4 lysyl hydroxylase activity Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. collagen lysine hydroxylase activity protocollagen lysine dioxygenase activity MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN protocollagen lysyl hydroxylase activity procollagen-lysine,2-oxoglutarate 5-dioxygenase activity lysine,2-oxoglutarate 5-dioxygenase activity protocollagen lysine hydroxylase activity procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating) peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity lysylprotocollagen dioxygenase activity lysine hydroxylase activity procollagen-lysine 5-dioxygenase activity lysine-2-oxoglutarate dioxygenase activity molecular_function biological_process The chemical reactions and pathways involving an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms. alkyne metabolism alkyne metabolic process phosphotyrosine binding molecular_function Interacting selectively with a phosphorylated tyrosine residue within a protein. PMID:14636584 biological_process UM-BBD_pathwayID:mf methyl fluoride metabolism The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils. methyl fluoride metabolic process biological_process The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. pyrimidine nucleoside triphosphate metabolism pyrimidine nucleoside triphosphate metabolic process cytochrome p450 XVIIA1 activity EC:1.14.99.9 steroid 17-alpha-monooxygenase activity steroid 17alpha-hydroxylase activity steroid 17alpha-monooxygenase activity molecular_function Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. steroid 17-alpha-hydroxylase activity cytochrome P45017alpha steroid 17alphahydroxylase/17,20 lyase activity cytochrome P450 CYP17 steroid 17-alpha-hydroxylase-C17-20 lyase activity cytochrome P-450 (P-45017alpha,lyase) steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) 17alpha-hydroxylase-C17,20 lyase activity MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN steroid 17-alpha-hydroxylase/17,20 lyase activity external side of outer membrane external side of cell outer membrane cellular_component The side of the outer membrane that is opposite to the side that faces the periplasm of the cell. GOC:mlg MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN EC:1.1.1.7 Catalysis of the reaction: propane-1,2-diol 1-phosphate + NAD+ = hydroxyacetone phosphate + NADH. molecular_function propanediol-phosphate dehydrogenase activity cellular_component PMID:17650307 PMID:11726501 PMID:11535616 PMID:10704439 A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. MCC mitotic checkpoint complex Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. PMID:14570579 R-SNARE activity t-SNARE activity Q-SNARE activity GO:0005485 SNARE v-SNARE activity GO:0005486 molecular_function SNAP-25 SNAP receptor activity The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. purine nucleotide catabolic process purine nucleotide degradation biological_process purine nucleotide breakdown purine nucleotide catabolism OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid. cellular_component centromere This term was made obsolete because it is genetically defined region and not a specific subcellular localization. To update annotations, consider cellular_component term 'chromosome, pericentric region ; GO:0000775' or its children. leucine/isoleucine/valine porter activity L-isoleucine transmembrane transporter activity leucine/valine/isoleucine permease activity L-isoleucine transporter activity molecular_function Catalysis of the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid. isoleucine/valine:sodium symporter activity CCR7 chemokine receptor ligand CCR7 chemokine receptor binding type 1 EBV-induced G-protein coupled receptor binding MIP-3 beta receptor binding Interacting selectively with a CCR7 chemokine receptor. GOC:nln molecular_function antigen processing and presentation of endogenous peptide antigen via MHC class II endogenous peptide antigen processing and presentation via MHC class II PMID:16181338 PMID:15531770 The process by which an antigen-presenting cell expresses an peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. biological_process 4-hydroxy-3-hexanone propanal-lyase activity EC:4.1.2.35 molecular_function 4-hydroxy-3-hexanone propanal-lyase (propanal-forming) MetaCyc:PROPIOIN-SYNTHASE-RXN Catalysis of the reaction: 2 propanal = 4-hydroxy-3-hexanone. 4-hydroxy-3-hexanone aldolase activity propioin synthase activity biological_process response to short exposure to lithium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus. PMID:10208444 Interacting selectively with a CCR5 chemokine receptor. molecular_function CCR5 chemokine receptor ligand CCR5 chemokine receptor binding TSC1-TSC2 complex tuberous sclerosis complex tuberin-hamartin complex A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. PMID:9580671 PMID:17121544 PMID:10585443 cellular_component AMP catabolic process biological_process AMP breakdown AMP catabolism The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate. AMP degradation pyrimidine nucleoside triphosphate catabolic process pyrimidine nucleoside triphosphate breakdown The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. biological_process pyrimidine nucleoside triphosphate degradation