gocvs GOA and proteome slim Candida GO slim PIR GO slim gene_ontology Generic GO slim 2008-01-04T19:30:00 Prokaryotic GO subset Yeast GO slim cvs version: $Revision: 1.522 $ Plant GO slim calcium channel activity molecular_function Reactome:13088 ISBN:0815340729 GOC:mtg_transport Catalysis of facilitated diffusion of an calcium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. ADP reduction This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider molecular_function term 'ADP reductase activity ; GO:0051061'. GOC:ai OBSOLETE (was not defined before being made obsolete). biological_process triacylglycerol metabolic process biological_process triglyceride metabolism triglyceride metabolic process triacylglycerol metabolism Oxford Dictionary of Biochemistry and Molecular Biology ISBN:0198506732 The chemical reactions and pathways involving triacylglycerol, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triacylglycerols are important components of plant oils, animal fats and animal plasma lipoproteins. MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN progesterone 11-alpha-hydroxylase activity EC:1.14.99.14 progesterone 11alpha-monooxygenase activity progesterone 11-alpha-monooxygenase activity progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating) molecular_function progesterone 11a-monooxygenase activity Catalysis of the reaction: progesterone + donor-H2 + O2 = 11-alpha-hydroxyprogesterone + acceptor + H2O. progesterone 11alpha-hydroxylase activity binding ligand molecular_function GOC:mah GOC:ceb The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. regulation of secondary metabolic process regulation of secondary metabolism Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. GOC:jl biological_process The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues other than as a moiety of nucleic acid. cell wall glycoprotein biosynthetic process cell wall glycoprotein formation cell wall glycoprotein biosynthesis cell wall glycoprotein synthesis cell wall glycoprotein anabolism biological_process PGJ receptor activity prostaglandin J receptor activity molecular_function Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. PMID:12878180 PGJ(2) receptor activity metallocarboxypeptidase D activity MetaCyc:3.4.17.22-RXN EC:3.4.17.22 Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid. molecular_function gp180 (duck) carboxypeptidase D (cattle, human, mouse, rat) EC:1.14.15.4 oxygenase, steroid 11beta -mono- steroid 11-beta/18-hydroxylase activity steroid 11-beta-monooxygenase activity Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. steroid 11-beta-hydroxylase activity steroid 11beta-hydroxylase activity cytochrome P450 CYP11B1 steroid 11beta-monooxygenase activity molecular_function cytochrome P450 CYP11B2 steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) steroid 11beta/18-hydroxylase activity MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN cytochrome p450 XIB1 activity biological_process purine nucleoside triphosphate catabolic process purine nucleoside triphosphate breakdown GOC:go_curators The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. purine nucleoside triphosphate catabolism purine nucleoside triphosphate degradation monoacylglycerol biosynthetic process monoacylglycerol biosynthesis monoacylglycerol synthesis monoacylglycerol anabolism biological_process The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. monoglyceride biosynthetic process monoacylglycerol formation monoglyceride biosynthesis EC:1.14.16.1 phenylalanine 4-hydroxylase activity phenylalanine 4-monooxygenase activity phenylalanine hydroxylase activity L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) PAH activity Reactome:12249 MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. phenylalaninase activity molecular_function EC:1.3.1.30 delta4-steroid 5alpha-reductase (progesterone) 5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity molecular_function progesterone 5-alpha-reductase activity steroid 5-alpha-reductase activity progesterone 5alpha-reductase activity MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH. progesterone 5a-reductase activity respiratory chain cytochrome b6 This term was made obsolete because the activity described by the definition does not exist. To update annotations, use molecular_function term 'electron carrier activity ; GO:0009055'. monoheme class I cytochrome c cytochrome c7 (triheme) cytochrome c3 (tetraheme) diheme class I cytochrome c electron transfer carrier molecular_function Rieske iron-sulfur protein class IIa cytochrome c cytochrome d cytochrome c554 class II cytochrome c flavodoxin cytochrome b class I cytochrome c class III cytochrome c nonaheme cytochrome c flavin-containing electron transporter OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells. high-molecular-weight cytochrome c (hexadecaheme) cytochrome b5 electron transporter activity class IIb cytochrome c class IV cytochrome c alkyne catabolic process alkyne degradation alkyne catabolism alkyne breakdown The chemical reactions and pathways resulting in the breakdown of an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms. http://en.wikipedia.org/ biological_process chitin- and beta-glucan-containing cell wall organization and biogenesis beta-glucan-containing cell wall organization and biogenesis cell wall organisation and biogenesis (sensu Fungi) biological_process GOC:mtg_sensu_feb07 A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the cell wall; as in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). chitin- and beta-glucan-containing cell wall organisation and biogenesis chitin-containing cell wall organization and biogenesis cell wall organization and biogenesis (sensu Fungi) EC:4.3.1.12 ornithine cyclase activity L-ornithine ammonia-lyase (cyclizing; L-proline-forming) ornithine cyclase (deaminating) activity ornithine cyclodeaminase activity MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN molecular_function L-ornithine ammonia-lyase (cyclizing) Catalysis of the reaction: L-ornithine = L-proline + NH3. OCD activity molecular_function PMID:12000961 Interacting selectively with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. phosphatidylserine binding EC:1.14.99.7 squalene-2,3-epoxide cyclase activity Catalysis of the formation of a 2,3-epoxide in squalene. MetaCyc:SQUALENE-MONOOXYGENASE-RXN squalene hydroxylase activity Reactome:12251 squalene oxydocyclase activity squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing) squalene monooxygenase activity squalene 2,3-oxidocyclase activity molecular_function squalene-2,3-epoxidase activity squalene epoxidase activity purine nucleoside triphosphate biosynthetic process biological_process purine nucleoside triphosphate formation purine nucleoside triphosphate synthesis purine nucleoside triphosphate anabolism purine nucleoside triphosphate biosynthesis The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. adenylate deaminase reaction This term was made obsolete because it represents a molecular function. To update annotations, use molecular_function term 'AMP deaminase activity ; GO:0003876'. OBSOLETE (was not defined before being made obsolete). biological_process biological_process Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. regulation of mammary gland epithelial cell proliferation molecular_function palmitoyl-(protein) hydrolase activity palmitoyl-protein thiolesterase activity MetaCyc:3.1.2.22-RXN palmitoyl-protein thioesterase activity palmitoyl-[protein] hydrolase EC:3.1.2.22 Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. palmitoyl-protein hydrolase activity B lymphocyte apoptosis programmed cell death of B cells by apoptosis programmed cell death, B lymphocytes B-lymphocyte apoptosis B cell apoptosis B-lymphocyte programmed cell death by apoptosis programmed cell death of B lymphocytes by apoptosis programmed cell death of B-cells by apoptosis apoptosis of B lymphocytes biological_process B lymphocyte programmed cell death by apoptosis programmed cell death, B-cells programmed cell death of B-lymphocytes by apoptosis apoptosis of B-cells apoptosis of B cells apoptosis of B-lymphocytes The process of apoptosis in B cells. Fundamental Immunology ISBN:0781735149 GOC:add B-cell apoptosis programmed cell death, B-lymphocytes B cell programmed cell death by apoptosis programmed cell death, B cells B-cell programmed cell death by apoptosis GOC:mtg_sensu A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall; as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). cell wall organization and biogenesis (sensu Bacteria) cell wall organisation and biogenesis (sensu Bacteria) biological_process peptidoglycan-based cell wall organization and biogenesis The chemical reactions and pathways resulting in the formation of an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms. alkyne synthesis alkyne formation alkyne biosynthesis alkyne anabolism biological_process alkyne biosynthetic process steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating) EC:1.14.99.10 molecular_function MetaCyc:STEROID-21-MONOOXYGENASE-RXN steroid 21-monooxygenase activity cytochrome P450 CYP21A1 21-hydroxylase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O. cytochrome p450 XXIA1 activity steroid 21-hydroxylase activity The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. pyrimidine nucleoside triphosphate formation pyrimidine nucleoside triphosphate biosynthetic process pyrimidine nucleoside triphosphate synthesis biological_process pyrimidine nucleoside triphosphate biosynthesis pyrimidine nucleoside triphosphate anabolism cAMP breakdown biological_process cAMP degradation 3',5'-cAMP catabolism 3',5'-cAMP catabolic process adenosine 3',5'-cyclophosphate catabolism adenosine 3',5'-cyclophosphate catabolic process cyclic AMP catabolism The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 3',5' cAMP catabolism cAMP catabolic process cyclic AMP catabolic process cAMP catabolism 3',5' cAMP catabolic process mammary gland epithelial cell proliferation The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. GOC:dph biological_process EC:2.4.1.50 collagen hydroxylysyl galactosyltransferase activity UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN procollagen galactosyltransferase activity UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine. hydroxylysine galactosyltransferase activity uridine diphosphogalactose-collagen galactosyltransferase activity molecular_function collagen galactosyltransferase activity UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity UDP galactose-collagen galactosyltransferase activity protein complex localization establishment and maintenance of protein complex localization The processes by which a protein complex is transported to, or maintained in, a specific location. biological_process prenol pyrophosphatase activity EC:3.1.7.1 prenyl-diphosphate diphosphohydrolase activity prenyl-diphosphatase activity prenylphosphatase activity MetaCyc:PRENYL-PYROPHOSPHATASE-RXN Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate. prenyl-pyrophosphatase activity molecular_function EC:1.14.11.4 lysyl hydroxylase activity Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. collagen lysine hydroxylase activity protocollagen lysine dioxygenase activity MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN protocollagen lysyl hydroxylase activity procollagen-lysine,2-oxoglutarate 5-dioxygenase activity lysine,2-oxoglutarate 5-dioxygenase activity protocollagen lysine hydroxylase activity procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating) peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity lysylprotocollagen dioxygenase activity lysine hydroxylase activity procollagen-lysine 5-dioxygenase activity lysine-2-oxoglutarate dioxygenase activity molecular_function biological_process The chemical reactions and pathways involving an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms. alkyne metabolism alkyne metabolic process phosphotyrosine binding molecular_function Interacting selectively with a phosphorylated tyrosine residue within a protein. PMID:14636584 biological_process UM-BBD_pathwayID:mf methyl fluoride metabolism The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils. methyl fluoride metabolic process biological_process The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. pyrimidine nucleoside triphosphate metabolism pyrimidine nucleoside triphosphate metabolic process cytochrome p450 XVIIA1 activity EC:1.14.99.9 steroid 17-alpha-monooxygenase activity steroid 17alpha-hydroxylase activity steroid 17alpha-monooxygenase activity molecular_function Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. steroid 17-alpha-hydroxylase activity cytochrome P45017alpha steroid 17alphahydroxylase/17,20 lyase activity cytochrome P450 CYP17 steroid 17-alpha-hydroxylase-C17-20 lyase activity cytochrome P-450 (P-45017alpha,lyase) steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) 17alpha-hydroxylase-C17,20 lyase activity MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN steroid 17-alpha-hydroxylase/17,20 lyase activity external side of outer membrane external side of cell outer membrane cellular_component The side of the outer membrane that is opposite to the side that faces the periplasm of the cell. GOC:mlg MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN EC:1.1.1.7 Catalysis of the reaction: propane-1,2-diol 1-phosphate + NAD+ = hydroxyacetone phosphate + NADH. molecular_function propanediol-phosphate dehydrogenase activity cellular_component PMID:17650307 PMID:11726501 PMID:11535616 PMID:10704439 A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. MCC mitotic checkpoint complex Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. PMID:14570579 R-SNARE activity t-SNARE activity Q-SNARE activity GO:0005485 SNARE v-SNARE activity GO:0005486 molecular_function SNAP-25 SNAP receptor activity The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. purine nucleotide catabolic process purine nucleotide degradation biological_process purine nucleotide breakdown purine nucleotide catabolism OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid. cellular_component centromere This term was made obsolete because it is genetically defined region and not a specific subcellular localization. To update annotations, consider cellular_component term 'chromosome, pericentric region ; GO:0000775' or its children. leucine/isoleucine/valine porter activity L-isoleucine transmembrane transporter activity leucine/valine/isoleucine permease activity L-isoleucine transporter activity molecular_function Catalysis of the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid. isoleucine/valine:sodium symporter activity CCR7 chemokine receptor ligand CCR7 chemokine receptor binding type 1 EBV-induced G-protein coupled receptor binding MIP-3 beta receptor binding Interacting selectively with a CCR7 chemokine receptor. GOC:nln molecular_function antigen processing and presentation of endogenous peptide antigen via MHC class II endogenous peptide antigen processing and presentation via MHC class II PMID:16181338 PMID:15531770 The process by which an antigen-presenting cell expresses an peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. biological_process 4-hydroxy-3-hexanone propanal-lyase activity EC:4.1.2.35 molecular_function 4-hydroxy-3-hexanone propanal-lyase (propanal-forming) MetaCyc:PROPIOIN-SYNTHASE-RXN Catalysis of the reaction: 2 propanal = 4-hydroxy-3-hexanone. 4-hydroxy-3-hexanone aldolase activity propioin synthase activity biological_process response to short exposure to lithium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus. PMID:10208444 Interacting selectively with a CCR5 chemokine receptor. molecular_function CCR5 chemokine receptor ligand CCR5 chemokine receptor binding TSC1-TSC2 complex tuberous sclerosis complex tuberin-hamartin complex A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. PMID:9580671 PMID:17121544 PMID:10585443 cellular_component AMP catabolic process biological_process AMP breakdown AMP catabolism The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate. AMP degradation pyrimidine nucleoside triphosphate catabolic process pyrimidine nucleoside triphosphate breakdown The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. biological_process pyrimidine nucleoside triphosphate degradation pyrimidine nucleoside triphosphate catabolism lysine permease activity L-lysine permease histidine/arginine/lysine/ornithine porter activity molecular_function GO:0005293 Catalysis of the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. L-lysine transmembrane transporter activity biological_process The assembly of chromatin into heterochromatin at the telomere. telomeric heterochromatin assembly telomeric heterochromatin formation molecular_function LARC receptor binding Interacting selectively with a CCR6 chemokine receptor. CCR6 chemokine receptor ligand CCR6 chemokine receptor binding antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent biological_process The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. PMID:15928678 TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, during the process of fermentation. biological_process ethanol synthesis during fermentation ethanol formation during fermentation ethanol anabolism during fermentation ethanol biosynthetic process during fermentation extrinsic to external side of outer membrane Loosely bound to the surface of the outer membrane of the cell that faces away from the cytoplasm, but not integrated into the hydrophobic region. cellular_component extrinsic to external side of cell outer membrane isovaleryl-CoA dehydrogenase activity isovaleroyl-coenzyme A dehydrogenase activity EC:1.3.99.10 molecular_function Reactome:24705 3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF. isovaleryl-coenzyme A dehydrogenase activity MetaCyc:ISOVALERYL-COA-DEHYDROGENASE-RXN 3-methylbutanoyl-CoA:acceptor oxidoreductase activity MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN EC:1.14.99.4 Catalysis of the reaction: progesterone + donor-H2 + O2 = testosterone acetate + acceptor + H2O. progesterone hydroxylase activity progesterone monooxygenase activity progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating) molecular_function ChEBI:28088 A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus. biological_process response to genistein EC:3.6.3.49 Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. cystic fibrosis transmembrane conductance regulator ATP phosphohydrolase (channel-conductance-controlling) molecular_function channel-conductance-controlling ATPase activity cystic-fibrosis membrane-conductance-regulating protein activity MetaCyc:3.6.3.49-RXN centric heterochromatin formation biological_process The assembly of chromatin into heterochromatin near the centromere. centromeric heterochromatin formation centromeric heterochromatin biosynthesis centric heterochromatin assembly ITP breakdown biological_process ITP degradation ITP catabolism ITP hydrolysis The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate. ITP catabolic process The expansion of a natural killer cell population by cell division. NK cell proliferation biological_process natural killer cell proliferation biological_process Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. regulation of cellular respiration diol dehydratase activity EC:4.2.1.28 propanediol dehydratase activity MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN Catalysis of the reaction: propane-1,2-diol = propanal + H2O. coenzyme B12-dependent diol dehydrase activity adenosylcobalamin-dependent diol dehydratase activity propanediol dehydrase activity meso-2,3-butanediol dehydrase activity molecular_function 1,2-propanediol dehydratase activity DL-1,2-propanediol hydro-lyase activity diol dehydrase activity propane-1,2-diol hydro-lyase activity propane-1,2-diol hydro-lyase (propanal-forming) dioldehydratase activity G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) A G-protein coupled signaling pathway that results in the activation of sphingosine kinase, causing an increase in cellular levels of sphingosine-1-phosphate. PMID:14592418 biological_process G-protein signalling, coupled to S1P second messenger (sphingosine kinase activating) G protein signalling, coupled to S1P second messenger (sphingosine kinase activating) G protein signaling, coupled to S1P second messenger (sphingosine kinase activating) internal side of cell outer membrane internal side of outer membrane The side of the outer membrane that faces the periplasm of the cell. cellular_component EC:1.10.3.2 Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. molecular_function laccase activity urushiol oxidase activity p-diphenol oxidase activity benzenediol:oxygen oxidoreductase activity MetaCyc:LACCASE-RXN urishiol oxidase activity response to hydroxyisoflavone biological_process ChEBI:38755 A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus. molecular_function Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. nucleocytoplasmic transporter activity cation diffusion facilitator activity GO:0015338 nonselective cation channel activity molecular_function cation channel activity Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. GOC:def GO:0015281 dIDP phosphorylation The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP. biological_process antibody dependent cell killing antibody dependent cell death antibody-dependent cell killing antibody-dependent cellular cytotoxicity biological_process antibody-dependent cell death PMID:9581795 PMID:11677095 Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells. ADCC type VI hypersensitivity heterochromatin formation The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent. biological_process heterochromatin assembly regulation of pentose-phosphate shunt biological_process regulation of pentose-phosphate pathway regulation of pentose phosphate shunt regulation of pentose phosphate pathway Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process by which glucose is oxidized, coupled to NADPH synthesis. hydrogen-transporting ATP synthase, F0 sector proton-transporting ATP synthase complex, coupling factor F(o) hydrogen-transporting ATP synthase, coupling factor CF(0) proton-transporting ATP synthase complex, coupling factor F(0) cellular_component All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. PMID:10838056 IL-19 production The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. biological_process interleukin-19 production molecular_function A triplet codon-amino acid adaptor activity that recognizes an AAG codon. AAG codon-amino acid adaptor activity Note that in the standard genetic code, AAG codes for lysine. biological_process The process by which an antigen-presenting cell expresses an peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. PMID:15771591 peptide antigen processing and presentation via MHC class II antigen processing and presentation of peptide antigen via MHC class II This term was added by GO_REF:0000021. cerebellar basket cell differentiation biological_process The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. PMID:15157725 GOC:mtg_15jun06 GOC:jic GOC:dgh GOC:cls limonene metabolic process UM-BBD_pathwayID:lim The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. http://umbbd.ahc.umn.edu/lim/lim_map.html biological_process limonene metabolism BRCA2-MAGE-D1 complex A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth. PMID:15930293 cellular_component 5-aminopentanamidase activity EC:3.5.1.30 5-aminonorvaleramidase activity molecular_function 5-aminopentanamide amidohydrolase activity MetaCyc:5-AMINOPENTANAMIDASE-RXN Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3. 5-aminovaleramidase activity prophase chromosome interphase chromosome chromatid ISBN:0198547684 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. chromosome cellular_component biological_process The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. IL-18 production interleukin-18 production phospholipid transfer to membrane The transfer of a phospholipid from its site of synthesis to the plasma membrane. biological_process biological_process PMID:15928680 The directed movement of a lipid antigen into, out of, within or between cells. lipid antigen transport IL-2 production biological_process The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. interleukin-2 production AAA codon-amino acid adaptor activity Note that in the standard genetic code, AAA codes for lysine. A triplet codon-amino acid adaptor activity that recognizes an AAA codon. molecular_function The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. proton-transporting ATP synthase complex, catalytic core F(1) (sensu Bacteria) plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) See also the cellular component term 'plasma membrane ; GO:0005886'. cellular_component hydrogen-transporting ATP synthase, F1 sector (sensu Bacteria) Lugaro cell differentiation This term was added by GO_REF:0000021. The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. biological_process biological_process iprodione metabolism UM-BBD_pathwayID:ipd iprodione metabolic process http://umbbd.ahc.umn.edu/ipd/ipd_map.html The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium). MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN Catalysis of the reaction: 5-alpha-ergosta-7,22-diene-3-beta,5-diol = ergosterol + H2O. EC:4.2.1.62 molecular_function 5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity 5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming) 5alpha-hydroxysteroid dehydratase activity 5-alpha-hydroxysteroid dehydratase activity cellular_component OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis. chromatid This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions. To update annotations, consider cellular_component terms 'chromosome ; GO:0005694' or its children, 'condensed chromosome ; GO:0000793' or its children, and 'condensed nuclear chromosome ; GO:0000794' or its children. molecular_function Facilitates the base-pairing of complementary single-stranded RNA. RNA strand annealing activity dihydrosphingosine-1-P pathway biological_process AAC codon-amino acid adaptor activity Note that in the standard genetic code, AAC codes for asparagine. A triplet codon-amino acid adaptor activity that recognizes an AAC codon. molecular_function The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family. biological_process lipid antigen assembly with MHC class Ib protein complex cellular_component hydrogen-transporting ATP synthase, stator stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core. proton-transporting ATP synthase, stator stalk biological_process The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. cerebellar granule cell differentiation This term was added by GO_REF:0000021. MetaCyc:5'-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN EC:3.6.1.20 molecular_function 5-phosphoadenosine hydrolase activity 5'-acylphosphoadenosine acylhydrolase activity Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate. 5'-acylphosphoadenosine hydrolase activity biological_process UM-BBD_pathwayID:mcr http://umbbd.ahc.umn.edu/mcr/mcr_map.html The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum. 3-hydroxybenzyl alcohol metabolism 3-hydroxybenzyl alcohol metabolic process oxygenase, dopamine beta-mono- EC:1.14.17.1 SDBH (soluble dopamine beta-monooxygenase) dopamine hydroxylase activity MDBH (membrane-associated dopamine beta-monooxygenase) dopamine beta-oxidase activity dopamine beta-monooxygenase activity dopamine-B-hydroxylase activity 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating) dopa beta-hydroxylase activity 4-(2-aminoethyl)pyrocatechol beta-oxidase activity dopamine b-hydroxylase activity phenylamine beta-hydroxylase activity (3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN molecular_function Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O. 3,4-dihydroxyphenethylamine beta-oxidase activity dopamine beta-hydroxylase activity propionyl-CoA synthetase activity EC:6.2.1.17 MetaCyc:PROPIONATE--COA-LIGASE-RXN propionate-CoA ligase activity molecular_function propanoate:CoA ligase (AMP-forming) Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA. phosphatidyl-N-monomethylethanolamine biosynthesis PMME biosynthetic process biological_process phosphatidyl-N-monomethylethanolamine biosynthetic process PMME biosynthesis phosphatidyl-N-monomethylethanolamine anabolism The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. phosphatidyl-N-monomethylethanolamine formation phosphatidyl-N-monomethylethanolamine synthesis response to ascorbic acid response to vitamin C response to L-ascorbate biological_process GOC:sl A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus. response to L-ascorbic acid cellular_component PMID:11352055 OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA. telomere This term was made obsolete because the definition was too sequence oriented and too restrictive. To update annotations, consider cellular_component terms 'chromosome, telomeric region ; GO:0000781' or its children and 'telomere cap complex ; GO:0000782' or its children. molecular_function A triplet codon-amino acid adaptor activity that recognizes an AAT codon. AAT codon-amino acid adaptor activity Note that in the standard genetic code, AAT codes for asparagine. ISBN:0838580343 A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. biological_process This term was added by GO_REF:0000021. locus ceruleus maturation biological_process The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. peptide antigen assembly with MHC class Ib protein complex proton-transporting ATP synthase complex, coupling factor F(0) (sensu Bacteria) cellular_component All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins. plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) proton-transporting ATP synthase complex, coupling factor F(o) (sensu Bacteria) hydrogen-transporting ATP synthase, F0 sector (sensu Bacteria) PMID:11884619 Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. cellular_component telomerase holoenzyme complex Roundup metabolic process UM-BBD_pathwayID:gly Roundup metabolism glyphosate metabolic process biological_process glyphosate metabolism The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond. http://umbbd.ahc.umn.edu/gly/gly_map.html EC:3.1.1.27 4-pyridoxolactone lactonohydrolase activity MetaCyc:4-PYRIDOXOLACTONASE-RXN Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate. molecular_function 4-pyridoxolactonase activity molecular_function prostaglandin-A1 delta-isomerase activity EC:5.3.3.9 (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity prostaglandin-A1 D-isomerase activity MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN Catalysis of the reaction: (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate. prostaglandin A isomerase activity interleukin-17 production biological_process IL-17 production The appearance of interleukin-17 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. phosphatidylethanolamine synthesis phosphatidylethanolamine formation biological_process phosphatidylethanolamine biosynthetic process phosphatidylethanolamine biosynthesis phosphatidylethanolamine anabolism The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. response to cobalamin A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus. response to vitamin B12 biological_process mineralocorticoid receptor binding molecular_function Interacting selectively with a mineralocorticoid receptor. PMID:12511169 MEK metabolism UM-BBD_pathwayID:mek MEK metabolic process biological_process The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints. http://umbbd.ahc.umn.edu/mek/mek_map.html methyl ethyl ketone metabolism methyl ethyl ketone metabolic process 2-butanone metabolism 2-butanone metabolic process The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. hydrogen-transporting ATP synthase, catalytic core cellular_component proton-transporting ATP synthase, catalytic core biological_process The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation. endosomal proteolysis associated with antigen processing and presentation proteolysis within endosome associated with antigen processing and presentation molecular_function Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate. EC:2.8.2.20 tyrosylprotein sulfotransferase activity 3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity protein-tyrosine sulfotransferase activity protein-tyrosine sulphotransferase activity MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN PMID:12960266 PMID:12752675 The process of apoptosis in neutrophils. apoptosis of neutrophils neutrophil apoptosis programmed cell death, neutrophils programmed cell death of neutrophils by apoptosis neutrophil programmed cell death by apoptosis biological_process interleukin-22 production The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. IL-22 production biological_process A triplet codon-amino acid adaptor activity that recognizes an ACG codon. ACG codon-amino acid adaptor activity Note that in the standard genetic code, ACG codes for threonine. molecular_function The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. biological_process This term was added by GO_REF:0000021. locus ceruleus formation biological_process The directed extracellular movement of carbohydrates. extracellular carbohydrate transport EC:3.6.1.29 dinucleosidetriphosphatase activity AP(3)Aase activity diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity molecular_function diadenosine 5,5-P1,P3-triphosphatase activity AP(3)A hydrolase activity bis(5'-adenosyl)-triphosphatase activity Catalysis of the reaction: P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP. MetaCyc:BIS(5'-ADENOSYL)-TRIPHOSPHATASE-RXN AP3Aase activity P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity AP3A hydrolase activity diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity 1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity snRNP U4atac cellular_component Ribonucleoprotein complex containing small nuclear RNA U4atac; a component of the minor spliceosome complex. GOC:krc cortisol receptor binding Interacting selectively with a cortisol receptor. molecular_function L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating) EC:1.14.13.9 kynurenine 3-monooxygenase activity molecular_function Reactome:12242 MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN kynurenine hydroxylase activity Catalysis of the reaction: L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O. L-kynurenine-3-hydroxylase activity kynurenine 3-hydroxylase activity proteolysis within endoplasmic reticulum associated with antigen processing and presentation proteolysis within ER associated with antigen processing and presentation ER proteolysis associated with antigen processing and presentation endoplasmic reticulum proteolysis associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation. PMID:15224092 biological_process proton-transporting ATP synthase, stator stalk (sensu Bacteria) cellular_component hydrogen-transporting ATP synthase, stator stalk (sensu Bacteria) plasma membrane proton-transporting ATP synthase, stator stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. biological_process OBSOLETE (was not defined before being made obsolete). methionine and threonine metabolic process This term was made obsolete because its use of 'and' was causing violations to the true-path rule. To update annotations, consider biological_process terms 'methionine metabolic process ; GO:0006555' or its children and 'threonine metabolic process ; GO:0006566' or its children. PMID:12956429 The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-lymphocyte homeostasis B-cell homeostasis B lymphocyte homeostasis biological_process Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. B cell homeostasis nucleoside hydrolase activity EC:3.2.2.1 nucleosidase activity MetaCyc:PURINE-NUCLEOSIDASE-RXN purine nucleoside hydrolase activity purine ribonucleosidase activity N-D-ribosylpurine ribohydrolase activity IAG-nucleoside hydrolase activity purine-nucleoside ribohydrolase activity Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose. N-ribosyl purine ribohydrolase activity IAG-NH activity purine beta-ribosidase activity purine nucleosidase activity inosine-adenosine-guanosine preferring nucleoside hydrolase activity purine nucleosidase reaction purine-specific nucleoside N-ribohydrolase activity nucleosidase g activity molecular_function ribonucleoside hydrolase activity biological_process The process by which the anatomical structure of the locus ceruleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. locus ceruleus morphogenesis This term was added by GO_REF:0000021. interleukin-23 production biological_process IL-23 production The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. biological_process The transport of substances that occurs outside cells. extracellular transport biological_process phospholipid metabolism The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. phospholipid metabolic process snRNP U6atac Ribonucleoprotein complex containing small nuclear RNA U6atac; a component of the minor spliceosome complex. cellular_component ecdysone modification molecular_function EC:1.14.99.22 alpha-ecdysone C-20 hydroxylase activity Catalysis of the reaction: ecdysone + donor-H2 + O2 = 20-hydroxyecdysone + acceptor + H2O. ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating) MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN ecdysone 20-monooxygenase activity ecdysone 20-hydroxylase activity methanesulphonic acid metabolism biological_process methanesulphonic acid metabolic process methanesulfonic acid metabolism UM-BBD_pathwayID:msa The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide. methanesulfonic acid metabolic process biological_process A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. PMID:11027914 response to corticosteroid stimulus proteosomal proteolysis associated with antigen processing and presentation biological_process The hydrolysis of a peptide bond or bonds within a protein by the proteosome complex contributing to antigen processing and presentation. proton-transporting ATP synthase, central stalk hydrogen-transporting ATP synthase, central stalk cellular_component One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis. locus ceruleus development This term was added by GO_REF:0000021. locus coeruleus development locus caeruleus development The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. biological_process The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. IL-20 production biological_process interleukin-20 production EC:2.7.1.35 pyridoxamine kinase activity vitamin B6 kinase activity Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. vitamin B(6) kinase activity MetaCyc:PYRIDOXKIN-RXN ATP:pyridoxal 5'-phosphotransferase activity pyridoxine kinase activity pyridoxal 5-phosphate-kinase activity pyridoxal kinase (phosphorylating) molecular_function pyridoxal kinase activity pyridoxal phosphokinase activity snRNP U11 Ribonucleoprotein complex containing small nuclear RNA U11; a component of the minor spliceosome complex. cellular_component membrane lipid metabolic process The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. membrane lipid metabolism biological_process Any process by which an organism avoids the immune response of a second organism by regulating the second organism's complement system, where the two organisms are in a symbiotic interaction. http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html active immune evasion via regulation of complement system of other organism active immune evasion via modulation of complement system of other organism biological_process active evasion of immune response of other organism via regulation of complement system of other organism during symbiotic interaction The directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. biological_process oligopeptide transport peptidylglycine 2-hydroxylase activity EC:1.14.17.3 PAM-A peptide alpha-amide synthase activity Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. peptidyl alpha-amidating enzyme activity synthase, peptide alpha-amide PAM-B PAM activity peptide alpha-amidating enzyme peptidylglycine alpha-hydroxylase activity molecular_function MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN peptidylglycine alpha-amidating monooxygenase activity peptidylglycine monooxygenase activity peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating) peptide-alpha-amide synthetase activity 3-hydroxytoluene metabolic process m-cresol metabolism MetaCyc:M-CRESOL-DEGRADATION-PWY meta-cresol metabolism biological_process 3-hydroxytoluene metabolism meta-cresol metabolic process m-cresol metabolic process The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes. neutrophil homeostasis Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. biological_process proteolysis associated with antigen processing and presentation biological_process The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation. hydrogen-transporting ATP synthase, catalytic core (sensu Bacteria) cellular_component The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. proton-transporting ATP synthase, catalytic core (sensu Bacteria) plasma membrane proton-transporting ATP synthase, catalytic core This term was added by GO_REF:0000021. cerebellar Purkinje cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. biological_process biological_process IL-21 production The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. interleukin-21 production queuine transfer ribonucleate ribosyltransferase activity EC:2.4.2.29 transfer ribonucleate glycosyltransferase activity tRNA guanine transglycosidase activity guanine insertion enzyme activity queuine tRNA-ribosyltransferase activity [tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. molecular_function guanine, queuine-tRNA transglycosylase activity tRNA transglycosylase activity tRNA-guanine transglycosylase activity Q-insertase activity The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of, within or between cells. biological_process eye pigment precursor transport snRNP U12 cellular_component Ribonucleoprotein complex containing small nuclear RNA U12; a component of the minor spliceosome complex. biological_process PMID:12439615 Any process by which an organism avoids the immune response of a second organism which directly affects the second organism's immune system, where the two organisms are in a symbiotic interaction. active immune evasion active evasion of immune response of other organism during symbiotic interaction triglyceride mobilization The release of triacylglycerols, any triester of glycerol, from storage within cells or tissues, making them available for metabolism. PMID:15713625 PMID:11943743 biological_process triacylglycerol mobilization EC:1.14.18.1 o-diphenol oxidoreductase N-acetyl-6-hydroxytryptophan oxidase activity tyrosinase activity polyphenolase activity monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity chlorogenic acid oxidase activity o-diphenol:oxygen oxidoreductase catecholase monophenol oxidase activity MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN monophenolase activity polyaromatic oxidase activity cresolase activity o-diphenol oxidase activity tyrosine-dopa oxidase activity dopa oxidase monophenol,L-dopa:oxygen oxidoreductase activity Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O. pyrocatechol oxidase phenol oxidase activity monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity prophenol oxidase o-diphenol:O2 oxidoreductase activity phenolase activity monophenol monooxidase activity chlorogenic oxidase activity monophenol monooxygenase activity PMID:2494997 monophenol oxygenase molecular_function delta-aminovalerate transaminase activity EC:2.6.1.48 delta-aminovalerate aminotransferase activity 5-aminovalerate transaminase activity MetaCyc:5-AMINOVALERATE-AMINOTRANSFERASE-RXN Catalysis of the reaction: 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate. 5-aminovalerate aminotransferase activity molecular_function 5-aminopentanoate:2-oxoglutarate aminotransferase activity UM-BBD_pathwayID:mca mandelate metabolism The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. mandelic acid metabolism mandelate metabolic process mandelic acid metabolic process biological_process The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. carotenoid metabolism biological_process carotenoid metabolic process 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) EC:2.2.1.5 2-hydroxy-3-oxoadipate synthase activity alpha-ketoglutaric-glyoxylic carboligase activity MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 . oxoglutarate: glyoxylate carboligase activity oxoglutarate:glyoxylate carboligase activity 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity 2-hydroxy-3-oxoadipate synthetase activity molecular_function catalase reaction CAT EC:1.11.1.6 Reactome:76029 Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. catalase-peroxidase activity catalase activity GO:0016953 equilase activity hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity heme catalase activity bacterial catalase-peroxidase activity molecular_function manganese catalase activity optidase activity MetaCyc:CATAL-RXN caperase activity haem catalase activity GO:0016952 response to lipopolysaccharide A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of lipopolysaccharide, a major component of the cell wall of gram-negative bacteria. ISBN:0721601464 biological_process response to LPS 5-hydroxypentanoate CoA-transferase activity MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN EC:2.8.3.14 Catalysis of the reaction: acetyl-CoA + 5-hydroxypentanoate = acetate + 5-hydroxy-pentanoyl-CoA. acetyl-CoA:5-hydroxypentanoate CoA-transferase activity 5-hydroxyvalerate CoA-transferase activity 5-hydroxyvalerate coenzyme A transferase activity molecular_function biological_process chemoperception detection of chemical substance The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. perception of chemical substance detection of chemical stimulus perception of chemical stimulus molecular_function MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN EC:1.1.1.16 Catalysis of the reaction: galactitol + NAD+ = D-tagatose + NADH. galactitol 2-dehydrogenase activity active evasion of immune response of other organism via regulation of cytokine network of other organism during symbiotic interaction biological_process Any process by which an organism avoids the immune response of a second organism by regulating the second organism's cytokine networks, where the two organisms are in a symbiotic interaction. http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation active immune evasion via regulation of cytokine network of other organism active immune evasion via modulation of cytokine network of other organism The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). biological_process ethanolamine catabolism ethanolamine degradation ethanolamine catabolic process ethanolamine breakdown MetaCyc:GALACTOLIPASE-RXN galactolipid lipase activity EC:3.1.1.26 galactolipase activity polygalactolipase activity 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity molecular_function galactolipid acylhydrolase activity Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates. candelabrum cell differentiation This term was added by GO_REF:0000021. biological_process The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. interleukin-16 production biological_process The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. IL-16 production down-regulation of protein amino acid autophosphorylation biological_process Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. downregulation of protein amino acid autophosphorylation down regulation of protein amino acid autophosphorylation inhibition of protein amino acid autophosphorylation negative regulation of protein amino acid autophosphorylation A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. biological_process basophil activation during immune response PMID:7729583 PMID:10751167 Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis. biological_process pseudocleavage EC:1.10.3.1 phenolase activity o-diphenol:oxygen oxidoreductase pyrocatechol oxidase tyrosinase activity dopa oxidase 1,2-benzenediol:oxygen oxidoreductase activity diphenol oxidase activity molecular_function catecholase o-diphenolase activity o-diphenol oxidoreductase catechol oxidase activity MetaCyc:CATECHOL-OXIDASE-RXN Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O. polyphenol oxidase activity EC:1.16.1.8 methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity methionine synthase cob(II)alamin reductase (methylating) activity [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity methionine synthase reductase activity molecular_function [methionine synthase] reductase activity Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+. Note that this was EC:2.1.1.135. methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing) MetaCyc:2.1.1.135-RXN 5-methyltetrahydrofolate-homocysteine methyltransferase reductase MetaCyc:CAROTENOID-PWY carotenoid synthesis carotenoid anabolism carotenoid biosynthesis carotenoid formation The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. biological_process carotenoid biosynthetic process response to muramyl dipeptide A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of muramyl dipeptide. Muramyl dipeptide is derived from peptidoglycan. biological_process propylmalic synthase activity EC:2.3.3.6 MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN Catalysis of the reaction: acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA . molecular_function (R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity 2-ethylmalate synthase activity 2-ethylmalate-3-hydroxybutanedioate synthase activity acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) propylmalate synthase activity ethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). ethanolamine formation biological_process ethanolamine anabolism ethanolamine synthesis ethanolamine biosynthesis L-asparagine transport The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of, within or between cells. biological_process asparagine transport active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism during symbiotic interaction active immune evasion via regulation of antigen processing and presentation in other organism active immune evasion via modulation of antigen processing/presentation in other organism active immune evasion via modulation of antigen processing and presentation in other organism active evasion of immune response of other organism via regulation of antigen processing and presentation pathway in other organism during symbiotic interaction Any process by which an organism avoids the immune response of a second organism by regulating the second organism's antigen processing or presentation pathways, where the two organisms are in a symbiotic interaction. biological_process molecular_function MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN EC:1.14.12.5 Catalysis of the reaction: 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+. 5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing) 5-pyridoxate oxidase activity 5-pyridoxate dioxygenase activity The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. IL-15 production biological_process interleukin-15 production hypotaurocyamine kinase activity molecular_function ATP:hypotaurocyamine N-phosphotransferase activity EC:2.7.3.6 Catalysis of the reaction: hypotaurocyamine + ATP = N(omega)-phosphohypotaurocyamine + ADP. MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. biological_process inferior olive development inferior olivary nucleus development This term was added by GO_REF:0000021. detection of nutrient perception of nutrients nutrient sensing biological_process The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal. detection of nutrients sorocarp formation fruiting body formation (sensu Dictyosteliida) sorocarp biosynthesis biological_process sorocarp development The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. ISBN:0521583640 DictyBase paper repository DDB_REF:2530 fruiting body development (sensu Dictyosteliida) The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. biological_process myeloid dendritic cell activation during immune response up-regulation of protein amino acid autophosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. positive regulation of protein amino acid autophosphorylation upregulation of protein amino acid autophosphorylation activation of protein amino acid autophosphorylation stimulation of protein amino acid autophosphorylation up regulation of protein amino acid autophosphorylation biological_process cerebroside-sulphatase activity cerebroside-sulfatase activity molecular_function EC:3.1.6.8 MetaCyc:CEREBROSIDE-SULFATASE-RXN arylsulfatase A activity cerebroside sulfate sulfatase activity cerebroside-3-sulfate 3-sulfohydrolase activity Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + SO4(2-) (sulfate). The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. carotenoid degradation biological_process carotenoid breakdown carotenoid catabolism carotenoid catabolic process response to peptidoglycan A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of peptidoglycan. Peptidoglycan is a bacterial cell wall macromolecule. biological_process GOC:cc The process by which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction. biological_process movement within other organism during symbiotic interaction Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. down-regulation of glucocorticoid catabolic process inhibition of glucocorticoid catabolic process biological_process downregulation of glucocorticoid catabolic process down regulation of glucocorticoid catabolic process negative regulation of glucocorticoid catabolic process phosphatidylethanolamine catabolic process phosphatidylethanolamine breakdown biological_process phosphatidylethanolamine catabolism phosphatidylethanolamine degradation The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. cellular_component GOC:ef The nerve ending is the structure in which the distal end of the axon of a nerve fiber terminates. Sensory nerve endings are classified as either free or encapsulated. The free nerve ending are the most common type of nerve ending, and are most frequently found in the skin. nerve ending nerve terminal EC:3.5.4.23 MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN blasticidin-S deaminase activity molecular_function blasticidin-S aminohydrolase activity Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3. geranyl pyrophosphate:(-)-endo-fenchol cyclase activity EC:4.2.3.10 molecular_function (-)-endo-fenchol cyclase activity Catalysis of the reaction: H2O + geranyl-PP = pyrophosphate + (-)-endo-fenchol. MetaCyc:4.2.3.10-RXN geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming] (-)-endo-fenchol synthase activity pyrimidine nucleotide transport The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. biological_process perception of biotic stimulus detection of biotic stimulus biological_process GO:0009596 GOC:hb The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. cerebellar stellate cell differentiation This term was added by GO_REF:0000021. biological_process The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. biological_process A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. myeloid leucocyte activation myeloid leukocyte activation interleukin-14 production IL-14 production The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. biological_process diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. DAG is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase C activity. DAG from phosphatidyl inositol polyphosphates is important in signal transduction. http://cancerweb.ncl.ac.uk/ diacylglycerol metabolism biological_process CCR4 chemokine receptor ligand Interacting selectively with a CCR4 chemokine receptor. molecular_function CCR4 chemokine receptor binding positive regulation of glucocorticoid catabolic process up-regulation of glucocorticoid catabolic process upregulation of glucocorticoid catabolic process activation of glucocorticoid catabolic process biological_process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. up regulation of glucocorticoid catabolic process stimulation of glucocorticoid catabolic process tripeptide transport biological_process The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of, within or between cells. antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway biological_process The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway carotene metabolic process biological_process The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids. carotene metabolism response to bacterial lipoprotein biological_process A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of bacterial lipoprotein. PMID:12077222 molecular_function chitin amidohydrolase activity EC:3.5.1.41 chitin deacetylase activity MetaCyc:CHITIN-DEACETYLASE-RXN Catalysis of the reaction: chitin + H2O = chitosan + acetate. biological_process The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction. migration within other organism during symbiotic interaction Interacting selectively with a microfibril, any small fibril occurring in biological material. molecular_function microfibril binding See also the cellular component term 'microfibril ; GO:0001527'. phosphatidylethanolamine metabolic process phosphatidylethanolamine metabolism The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. biological_process EC:1.13.12.6 Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light. MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN Cypridina luciferase activity luciferase activity molecular_function luciferase (Cypridina luciferin) Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating) Cypridina-luciferin 2-monooxygenase activity Cypridina-type luciferase activity cypridina-type luciferase activity Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN EC:2.7.1.92 5-keto-2-deoxygluconokinase activity ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity DKH kinase activity 5-keto-2-deoxyglucono kinase (phosphorylating) 5-dehydro-2-deoxygluconokinase activity molecular_function amino acid transport biological_process The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells. GO:0006866 cerebellar unipolar brush cell differentiation This term was added by GO_REF:0000021. The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex. biological_process interleukin-13 production IL-13 production The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. biological_process A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. biological_process myeloid cell activation during immune response regulation of protein amino acid autophosphorylation biological_process Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. pseudocleavage during syncytial blastoderm formation pseudocleavage (sensu Insecta) Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos in the syncytial blastoderm stage. biological_process antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. biological_process dipeptide transport The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells. biological_process AGG codon-amino acid adaptor activity Note that in the standard genetic code, AGG codes for arginine. A triplet codon-amino acid adaptor activity that recognizes an AGG codon. molecular_function MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN EC:1.3.7.1 Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin. HNA reductase activity 6-hydroxynicotinate reductase activity 6-oxotetrahydronicotinate dehydrogenase activity molecular_function 6-hydroxynicotinic reductase activity 6-oxotetrahydro-nicotinate dehydrogenase activity 1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity 6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity 3-methylquinoline metabolic process biological_process The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring. UM-BBD_pathwayID:mqn 3-methylquinoline metabolism The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction. biological_process acquisition of nutrients from other organism during symbiotic interaction nucleotide transport The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. biological_process very-long-chain-fatty-acid-CoA ligase activity very-long-chain fatty acid activation molecular_function Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18. EC:6.2.1.3 very-long-chain fatty acid-CoA ligase activity tripeptide transporter activity molecular_function Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of, within or between cells. proton-transporting ATP synthase, central stalk (sensu Bacteria) One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. hydrogen-transporting ATP synthase, central stalk (sensu Bacteria) cellular_component plasma membrane proton-transporting ATP synthase, central stalk perception of virus biological_process The series of events in which a stimulus from a virus is received and converted into a molecular signal. detection of virus indanol dehydrogenase activity molecular_function MetaCyc:INDANOL-DEHYDROGENASE-RXN EC:1.1.1.112 Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. indan-1-ol:NAD(P)+ 1-oxidoreductase activity molecular_function A triplet codon-amino acid adaptor activity that recognizes a GTT codon. Note that in the standard genetic code, GTT codes for valine. GTT codon-amino acid adaptor activity purine transport biological_process The directed movement of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells. GO:0015852 regulation of morphology of other organism modification of morphology or physiology of other organism during symbiotic interaction biological_process regulation of physiology of other organism regulation of morphology or physiology of other organism during symbiotic interaction regulation of physiological process in other organism modulation of morphology or physiology of other organism during symbiotic interaction The process by which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction. EC:4.1.1.52 6-methylsalicylate carboxy-lyase (3-cresol-forming) 6-methylsalicylate carboxy-lyase activity MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN molecular_function 6-MSA decarboxylase activity Catalysis of the reaction: 6-methylsalicylate = 3-cresol + CO2. 6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity 6-methylsalicylate decarboxylase activity naphthalene metabolic process UM-BBD_pathwayID:naph naphthalene metabolism http://www.iversonsoftware.com/reference/chemistry/n/Naphthalene.htm The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide. biological_process detection of peptidoglycan The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule. biological_process PMID:12606724 Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor. corticosteroid receptor signalling pathway biological_process corticosteroid receptor signaling pathway respiratory chain complex I Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'. NADH-Q oxidoreductase complex cellular_component NADH dehydrogenase complex (ubiquinone) Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. ISBN:0716749556 NADH dehydrogenase (ubiquinone) complex GO:0045279 Catalysis of the reaction: indole + O2 = 2-formylaminobenzaldehyde. MetaCyc:INDOLE-2,3-DIOXYGENASE-RXN EC:1.13.11.17 indole:oxygen 2,3-oxidoreductase (decyclizing) indole:O2 oxidoreductase activity IDO molecular_function indole-oxygen 2,3-oxidoreductase (decyclizing) indole oxidase activity indole 2,3-dioxygenase activity dipeptide transporter activity Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells. molecular_function EC:3.1.1.33 6-acetyl-D-glucose acetylhydrolase activity 6-O-acetylglucose deacetylase activity 6-acetylglucose deacetylase activity MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate. molecular_function biological_process neutral lipid metabolism The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. neutral lipid metabolic process disruption of cells of other organism during symbiotic interaction biological_process A process by which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. extracellular amino acid transport biological_process The directed extracellular movement of amino acids. biological_process The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan. PMID:15998797 GOC:rl detection of muramyl dipeptide The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. biological_process eosinophil activation during immune response short-chain-fatty-acid-CoA ligase activity Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids have chain lengths of less than 8 carbons. molecular_function short-chain fatty acid activation short-chain fatty acid-CoA ligase activity The directed movement of achromobactin, a citrate siderophore, into, out of, within or between cells. PMID:10928541